Read this before you compare prices
The FDA declared the tirzepatide shortage resolved in December 2024 and the semaglutide shortage resolved in February 2025, which ended the window for compounding pharmacies to make large volumes of copies of those drugs (503A pharmacies had until April 22, 2025; 503B outsourcing facilities until May 22, 2025). Many telehealth companies continue to offer compounded GLP-1s prescribed for an individual patient — often as a personalized dose, a microdose, or a formulation combined with a vitamin such as B12 or B6. That practice sits in a contested legal area, and the FDA has continued to act. In a Federal Register notice published on May 1, 2026, the FDA proposed not to include semaglutide, tirzepatide or liraglutide on the 503B bulks list, saying it had not identified sufficient evidence of a clinical need for outsourcing facilities to compound them from bulk substances; the comment period was extended to July 30, 2026. Separately, in February 2026 the FDA issued warning letters to 30 telehealth companies over false or misleading claims about compounded GLP-1s, and it has continued: a further round dated 8 June 2026 — 25 warning letters, posted publicly on 16 June 2026 — reached companies including Medica Weight Loss, FITISH and Roen Health (RoenRx), again over false or misleading claims about compounded semaglutide and tirzepatide that the FDA said made the products misbranded under sections 502(a) and 502(bb) of the FD&C Act. The claims cited included suggesting the products were FDA-approved, implying equivalence to Ozempic, Wegovy, Mounjaro or Zepbound, and asserting the "same active ingredient" or "same results" as the approved drugs. Compounded medications are not FDA-approved, which means they have not gone through the same review as the brand-name products.
None of that is a reason to panic if you are currently on a compounded GLP-1 — it is a reason to understand what you are buying, and to know that your provider's ability to keep supplying it is not guaranteed indefinitely.
Our Picks, Ranked by Total Cost and Quality
Ranked on what you actually pay each month once membership and medication are added together, weighted against clinical access and how clearly each provider publishes its terms.
Ondra Health
Why it's here: The lowest published compounded semaglutide price in our research, held flat across every dose — and the only provider on this list that publicly names all five compounding pharmacies filling its prescriptions, a disclosure it issued a press release about.
Watch out for: Nationwide only since May 2026, so there is no long operating record. The $96 and $142 rates require a 12-month prepayment; monthly billing is $149 and $219.
Read the full Ondra Health review →Trimi
Why it's here: The lowest compounded tirzepatide price we found anywhere, with one flat membership covering medication, clinician visits, and shipping. It names both compounding pharmacies and publishes a state licence number for one of them, which no other provider here does.
Watch out for: Those rates need annual billing — tirzepatide is $235/month billed monthly. Once a prescription is issued the order is final under Trimi's own policy, so "cancel anytime" has a hard cutoff. Trustpilot has also removed fake reviews from its profile.
Read the full Trimi review →Yucca Health
Why it's here: The lowest published compounded pricing in our research, with no separate membership fee to add on. At $125/month for semaglutide on a 6-month plan ($750 total), it undercuts every two-part competitor once their fees are counted, and it needs a shorter commitment than the two providers above it.
Watch out for: The six-month plan is paid upfront at $750, and no refund terms are published against it. Month-to-month is now published too, at $146 — only about 17% more, which is the smallest commitment penalty in this table.
Read the full Yucca Health review →Amble
Why it's here: The clearest volume-pricing ladder in this market — $179, $160, $145, $135 per month at 1, 3, 6, and 12 months. It also states that FDA-approved or compounded medication is dispensed depending on the plan, which gives you a path to approved medication without switching providers.
Watch out for: The $135 rate requires paying twelve months up front. Its homepage separately advertises "plans from $99/mo," which does not match the published injection ladder — ask which product that refers to.
Read the full Amble review →Alloy
Why it's here: Roughly $169 to $199/month all-in, with unlimited messaging included and menopause-trained physicians who can consider hormone therapy and weight treatment together.
Watch out for: Built specifically for women in perimenopause and menopause. Outside that population, a general-purpose provider fits better.
Read the full Alloy review →Fridays
Why it's here: A very low effective monthly rate with no membership, sign-up or lab fees, unlimited provider visits and coaching included, and unusually honest published language about what compounded medication is and is not. It now also lists brand-name Wegovy at $98/mo on annual prepay — cheaper than its own compounded semaglutide.
Watch out for: The good rates need annual prepay, and month-to-month roughly doubles them. Fridays also states a minimum BMI of 20, which sits inside the healthy range and well below the approved indications — see our review.
Read the full Fridays review →Mochi Health
Why it's here: One medication price across every published dose, with shipping included and both halves of the bill stated clearly. The easiest provider on this list to budget for twelve months out.
Watch out for: Roundups that quote only "$99/mo" understate your total by nearly half. Mochi does not publicly name its compounding pharmacy.
Read the full Mochi Health review →Ivím Health
Why it's here: Unlimited visits, same-day availability, and no waitlist to see your own provider. If side effects during titration worry you, this is the most generous access on the list, and long plans push medication pricing very low.
Watch out for: Membership is mandatory for the full length of your medication plan, and some plans price medication by dose — ask what you pay at maintenance.
Read the full Ivím Health review →TrimRx
Why it's here: A single monthly figure that covers medication and care, with nothing to add on. For anyone tired of two-part pricing, that clarity has real value, and longer plans lower the rate.
Watch out for: Once you add competitors' membership fees, TrimRx is not actually cheaper than the two-part providers above it. Much of the published material about TrimRx comes from TrimRx.
Read the full TrimRx review →Henry Meds
Why it's here: Oral and sublingual compounded formats that almost no competitor offers, with visit, medication, and supplies bundled into one plan price and real discounts for paying in full.
Watch out for: Pricing lives in a legal programs document, published figures vary widely by format and plan length, and Henry operates in a limited set of states.
Read the full Henry Meds review →Brello Health
Why it's here: Same price at every dose, with provider review, medication, shipping, and support in one charge and fast advertised 2–3 day shipping.
Watch out for: The advertised monthly figure is the quarterly total divided by three — you are charged the full quarter up front, with a 3-month minimum.
Read the full Brello Health review →Eden
Why it's here: Genuinely low entry medication pricing, both molecules available, and an unusually deep published education library.
Watch out for: The least consistent pricing of any provider we researched — figures conflict across Eden's own pages, and the membership reportedly added in 2026 roughly doubles the widely quoted $99. Get a written quote before paying.
Read the full Eden review →ScriptsMD
Why it's here: One of the very few providers anywhere that names the pharmacy dispensing your medication — its terms specify Curexa Pharmacy LLC "or another pharmacy of your choice". It also uses flat per-dose pricing, so titrating up does not raise your bill, and bundles a registered dietitian and a certified trainer into the membership rather than upselling them.
Watch out for: Its refund policy page returns a 404, and the advertised "100% service satisfaction guarantee" has no published terms — get both in writing first. The $84 medication figure is an "as low as" price, and five states are excluded: Louisiana, Hawaii, Alaska, Pennsylvania and South Carolina.
Read the full ScriptsMD review →Coby Health
Why it's here: The most complete regulatory disclosure in this comparison. Coby states on every product that compounded semaglutide "is not reviewed or approved by the FDA", "is not a generic form of Ozempic® and Wegovy®", and that it "has no affiliation with Novo Nordisk" — the exact representations the FDA pursued other companies for getting wrong. Pricing is all-in, no subscription is required, and the full dose-by-dose schedule is published.
Watch out for: This is the starter-dose illusion described above, made explicit: the price climbs with every titration step, so the $159 you see is the month you pay least. Budget $249. A $50 visit fee is non-refundable even on a successful cancellation, nothing is refundable once shipped, and it does not serve AR, LA, MS or NM.
Read the full Coby Health review →Total Monthly Cost, Side by Side
The single most useful table on this page. Headline prices are what providers advertise; all-in is what leaves your account.
| Provider | Membership | Semaglutide | Tirzepatide | All-in (sema) |
|---|---|---|---|---|
| Ondra Health | None | from $96/mo (12-mo plan) | from $142/mo (12-mo plan) | ~$96/mo |
| Trimi | None | $99/mo (annual), $235 monthly | $125/mo (annual), $235 monthly | ~$99/mo |
| Yucca Health | None | from $125/mo (6-mo plan) | from $225/mo (3-mo plan) | ~$125/mo |
| Fifty 410 | None | from $199/mo | from $133/mo (3-mo program) | ~$133–$199/mo |
| Good Life Meds | None | $199 per purchase | $197–$297 per purchase | ~$199/mo |
| Rixa Health | None | $195–$290 per 4–5 week cycle by dose | not published | ~$195+/cycle |
| Alan Meds | None | $297 first month, $397/mo after | not published | ~$397/mo |
| Amble | None | $135–$179/mo by plan length | varies by dose | ~$135–$179/mo |
| Fridays | None | $117–$150/mo annual, $249/mo monthly | $198–$240/mo annual, $359/mo monthly | ~$117–$249/mo |
| Alloy | $99/mo | from $70/mo | from $100/mo | ~$169/mo |
| EllieMD | None | from ~$299/mo (microdose ~$239) | from ~$379/mo | ~$239–$299/mo |
| Willow | None | $299/mo (injection or oral tablet) | $399/mo, to ~$524/mo at 15mg | ~$299/mo |
| MEDVi | None | $179 first month, then $299/mo | $279 first month, then $399/mo | ~$299/mo |
| Mochi Health | $79/mo | $99/mo all doses | $199/mo all doses | ~$178/mo |
| Ivím Health | $74.99/mo | from ~$75–$149/mo | varies by plan | ~$150–$224/mo |
| Eden | reported $99/mo | $99/mo advertised | $199/mo advertised | ~$198/mo |
| TrimRx | None | from $199/mo | from $299/mo | ~$199/mo |
| Brello Health | None | $399/quarter | $499/quarter | ~$133/mo prepaid |
| Henry Meds | None | from $179/mo on long plans | from $349/mo (oral) | ~$179/mo |
All figures as published in August 2026. Sources for each are listed in the individual provider reviews.
Five Questions to Ask Any Compounded Provider
1. Which pharmacy fills my prescription?
Most providers on this list will not tell you publicly. A provider willing to name its pharmacy, and to confirm whether it is a 503A pharmacy or a 503B outsourcing facility, is giving you something you can actually verify. One that deflects the question is telling you something too.
2. What will I pay at my maintenance dose?
Starter-dose pricing is the industry's favourite illusion. Flat-price providers (Mochi, Brello) are honest about this by design. Everyone else should be asked directly.
3. Is the membership fee separate, and is it required?
At Ivím it is mandatory and tied to your plan length. At Eden it was reportedly added in 2026. At Mochi and Alloy it is stated up front. Ask, then add it to the medication price before comparing anything.
4. What am I committing to?
Brello charges a full quarter up front with a 3-month minimum. Henry sells multi-month bundles. Longer commitments almost always mean lower per-month pricing — and a bigger loss if you cannot tolerate the medication.
5. What happens if the FDA restricts this further?
A fair question to ask any compounded provider in 2026, and worth asking before you prepay for six months. Providers that also offer brand-name medication — Mochi, Eden, Found — can at least transition you. Compounded-only providers cannot.
A genuine alternative worth pricing
Before committing to compounded medication on price alone, check the manufacturer pharmacies. NovoCare Pharmacy publishes brand-name Wegovy at $149/month for the pill and $199/month for the pen, with no membership. That is competitive with several providers on this page — for an FDA-approved product.
Frequently Asked Questions
Is compounded semaglutide still legal in 2026?
The picture is more complicated than a simple yes or no. The FDA declared the tirzepatide shortage resolved in December 2024 and the semaglutide shortage resolved in February 2025, which closed the window for compounders to produce copies of those drugs — 503A pharmacies had until April 22, 2025 and 503B outsourcing facilities until May 22, 2025. Companies still offering compounded GLP-1s generally frame them as patient-specific personalized formulations. That practice sits in a contested legal area and the FDA has signaled further action.
Which compounded provider has the lowest total cost?
On published figures, Ondra Health is lowest for semaglutide at $96/month on a 12-month plan, and Trimi is lowest for tirzepatide at $125/month on an annual plan. Yucca Health follows at $125/month semaglutide on a 6-month plan, then Amble at $135/month on a 12-month plan. None of these charges a separate membership fee. Alloy comes to roughly $169 to $199/month all-in ($99 care plus medication from $70). Mochi Health is $178/month for semaglutide and $278/month for tirzepatide, with the advantage of flat pricing at every dose.
Is compounded medication less effective than brand-name?
Compounded semaglutide and tirzepatide contain the same active molecules, so the mechanism is the same. What differs is that compounded products have not gone through FDA review, so their potency, purity, and consistency have not been verified in the same way. There is no clinical trial evidence for compounded formulations specifically, including versions combined with vitamins like B12 or B6.
Does insurance ever cover compounded GLP-1s?
No. Compounded medications are not FDA-approved and are not reimbursable by insurance anywhere. Every compounded provider on this page is cash-pay by definition. If coverage matters to you, you need an FDA-approved medication and a provider that prescribes one.
Related Reading
- Brand-name vs compounded GLP-1s — the full trade-off, including the regulatory history
- Best semaglutide compounding pharmacy
- Best tirzepatide compounding pharmacy
- Storing and shipping GLP-1s — what to do when a cold-chain shipment arrives warm
Medical Disclaimer
We're not doctors, and this article is for education only — it isn't medical advice. GLP-1 medications are prescription-only and require evaluation by a licensed healthcare provider. Individual results vary widely, and only a clinician who knows your history can determine what is safe and appropriate for you. See our full medical disclaimer.
Keep Comparing
Every provider we've researched, with published pricing, medication type, and what's actually included.
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