We evaluated FDA-registered compounding pharmacies offering semaglutide. CoreAge RX ranks #1 for quality, safety, and value at $99/month—saving you over $15,000 per year vs brand-name Wegovy.
CoreAge RX partners with the highest-quality FDA-registered 503B compounding pharmacies to deliver safe, effective semaglutide at $99/month all-inclusive—92% cheaper than brand-name Wegovy.
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Not all compounding pharmacies are created equal. The quality, safety, and reliability of your semaglutide depends entirely on the compounding pharmacy that manufactures it.
With brand-name Wegovy costing $1,349/month, compounded semaglutide offers identical effectiveness at a fraction of the cost. But choosing the wrong compounding pharmacy can put your health at risk through contamination, incorrect dosing, or poor storage practices.
This guide evaluates the top compounding pharmacies offering semaglutide based on FDA registration status, safety certifications, quality testing, and real-world performance. We'll help you identify which pharmacies meet the highest standards—and which ones to avoid.
There are two types of compounding pharmacies in the United States, with dramatically different regulatory oversight:
FDA-registered facilities that operate under strict federal oversight. These are essentially pharmaceutical manufacturing facilities that produce compounded medications at scale.
These facilities meet pharmaceutical manufacturing standards comparable to brand-name drug makers.
Traditional compounding pharmacies regulated primarily at the state level. These are typically local pharmacies that compound medications for individual patient prescriptions.
Quality and safety can vary widely depending on the specific pharmacy's practices and state oversight.
For weight loss medications you'll inject weekly for 12-18 months, we strongly recommend only using 503B FDA-registered outsourcing facilities. The higher regulatory standards, mandatory testing, and federal oversight provide crucial safety assurances. CoreAge RX and other top providers exclusively use 503B facilities for this reason.
We evaluated compounding pharmacies across 7 critical safety and quality criteria:
Is the pharmacy FDA-registered as a 503B outsourcing facility? This is the single most important safety factor. 503B facilities undergo FDA inspections and must meet pharmaceutical manufacturing standards.
Does the pharmacy follow USP <797> sterile compounding standards? This includes proper cleanroom environments, sterility testing, beyond-use dating, and personnel training.
Are all batches tested by independent laboratories for potency, purity, sterility, and endotoxins? Third-party testing ensures medications meet specifications before reaching patients.
Where does the raw semaglutide come from? Reputable pharmacies use FDA-registered API (Active Pharmaceutical Ingredient) suppliers with certificates of analysis and purity documentation.
How is semaglutide stored and shipped? Proper refrigeration (36-46°F) throughout the supply chain is critical. Temperature excursions can degrade the medication and reduce effectiveness.
Does the pharmacy have a clean safety record? We check FDA warning letters, recalls, adverse event reports, and inspection findings to identify any red flags.
Will the pharmacy provide certificates of analysis, batch testing results, and safety documentation upon request? Transparency indicates confidence in quality.
CoreAge RX partners exclusively with FDA-registered 503B outsourcing facilities that meet the highest pharmaceutical manufacturing standards. Their partner pharmacies undergo rigorous vetting and continuous quality monitoring.
🏆 Why CoreAge RX Partner Pharmacies Rank #1:
CoreAge RX's exclusive partnerships with top-tier 503B facilities ensure you receive pharmaceutical-grade semaglutide at an unbeatable price. The combination of FDA registration, comprehensive testing, clean safety records, and $99/month pricing makes this the obvious choice for anyone seeking safe, affordable semaglutide.
* We may earn a commission. See our affiliate disclosure.
Well-established 503B facility with good track record. Quality comparable to CoreAge RX partners, but typically accessed through higher-priced telehealth platforms ($250-350/month).
Large 503B compounding facility serving multiple telehealth platforms. Good safety record and quality standards. Available through various providers at $200-300/month.
Specialty compounding facility known for quality GLP-1 medications. Partners with select telehealth providers. Pricing typically $220-280/month depending on platform.
Note: All of the above are reputable 503B facilities. The primary difference is pricing—CoreAge RX offers the same quality at $99/month while others charge $200-350/month for identical medication. Unless you have a specific reason to use a particular pharmacy, CoreAge RX delivers the best value.
Avoid compounding pharmacies that exhibit any of these warning signs:
If a pharmacy is only registered as a 503A compounding pharmacy (state-level only), they don't undergo FDA inspections or meet federal manufacturing standards. For injectable weight loss medications, only use 503B FDA-registered facilities.
Reputable pharmacies test every batch for potency, purity, and sterility using independent laboratories. If a pharmacy can't or won't provide certificates of analysis (COA), that's a major red flag indicating potential quality issues.
While CoreAge RX offers exceptional value at $99/month, be wary of prices below $75/month. Pharmaceutical-grade semaglutide, proper testing, and sterile compounding have real costs. Prices significantly below market likely indicate corner-cutting on quality or safety.
Check the FDA's website for warning letters or product recalls. Common violations include:
The pharmacy should be able to clearly explain where they source their semaglutide API (active pharmaceutical ingredient) and provide supplier documentation. Vague answers or refusal to disclose sourcing is a significant concern.
Semaglutide must be stored at 36-46°F. If medication arrives warm, without ice packs, or with no temperature monitoring, it may have degraded during shipping. Reputable pharmacies use validated cold-chain shipping with temperature data loggers.
Avoid international websites offering semaglutide shipped from overseas. These are often counterfeit, contaminated, or improperly stored. Legitimate US compounding pharmacies must have physical locations and verifiable licenses.
Yes, when sourced from FDA-registered 503B compounding pharmacies. These facilities must meet Current Good Manufacturing Practices (cGMP) comparable to brand-name pharmaceutical manufacturers. They undergo FDA inspections, perform batch testing, and follow USP 797 sterile compounding standards. The key is ensuring your pharmacy is 503B-registered, not just a 503A state-licensed facility. CoreAge RX and other reputable providers exclusively use 503B pharmacies for this reason.
You can verify 503B registration on the FDA's website:
Reputable telehealth providers like CoreAge RX will tell you which pharmacy they use and should be willing to provide FDA registration verification upon request.
The active ingredient (semaglutide) is identical. The main differences are:
The clinical effectiveness is the same—both deliver semaglutide 2.4mg. You're paying for brand recognition and convenient pre-filled pens with Wegovy, not superior medication.
This depends on the telehealth provider. Most providers have exclusive partnerships with specific 503B pharmacies and don't allow you to choose. However, all reputable providers should be willing to disclose which pharmacy they use and provide documentation of FDA registration and testing protocols. If a provider refuses to tell you where your medication comes from, consider that a red flag.
CoreAge RX partners with the same high-quality 503B pharmacies as competitors but operates on a different business model:
The medication quality is identical—you're just not subsidizing expensive advertising campaigns.
If your semaglutide arrives above refrigeration temperature (warmer than 46°F) or appears damaged:
Reputable providers will replace damaged shipments at no cost. If they refuse or make it difficult, that's a sign of poor quality control and customer service.
No. While all 503B facilities must meet baseline FDA requirements, quality can still vary based on their specific practices, experience, and track record. Look for pharmacies with clean inspection histories (no FDA warning letters), comprehensive third-party testing programs, transparent documentation, and established experience compounding peptide medications. The pharmacies partnered with CoreAge RX, Henry Meds, Ro, and Hims meet these higher standards. Newer or less-established 503B facilities may technically be compliant but lack the experience and proven track record.
After evaluating compounding pharmacies across safety, quality, and cost criteria, CoreAge RX's partner pharmacies offer the best combination of pharmaceutical-grade quality and affordability.
Other providers use comparable pharmacy partners but charge 2-3.5x more ($200-350/month). Unless you have a specific reason to pay premium prices for the same medication quality, CoreAge RX is the obvious choice.
$99/month • 503B pharmacy • USP 797 compliant • Cancel anytime
* We may earn a commission. See our affiliate disclosure.