THC Pushes Appetite the Opposite Way

The “munchies” is a joke with a well-characterised mechanism behind it, and that mechanism happens to run straight through the system GLP-1 medications act on.

THC activates CB1 cannabinoid receptors. That activation raises ghrelin — the hormone that signals hunger — partly by reducing peptide YY (PYY), a satiety signal, and partly by activating the mTOR pathway. The effect is not incidental to appetite regulation; it is central to it. In animal work, ghrelin failed to produce its usual appetite-stimulating effect in mice lacking CB1 receptors, and blocking CB1 pharmacologically inhibited ghrelin's downstream signalling. The cannabinoid system and the hunger-hormone system are wired together.

Your GLP-1 medication is doing the reverse: suppressing appetite and raising satiety signalling. So regular THC use while taking one is, quite literally, paying to push a system in two directions at once. It does not make the medication unsafe. It does make it work against a headwind you have added yourself.

CBD is a separate matter

CBD does not activate CB1 the way THC does and is not intoxicating, so the appetite mechanism above does not apply to it. The considerations with CBD are different — mainly liver-enzyme interactions with other medications, and product quality in a category where labelling is inconsistent. If you use cannabinoid products and want to avoid the appetite problem, the practical rule is simple: check whether the product is broad spectrum, meaning THC-free, or full spectrum, meaning it contains THC.

And what about THCV?

THCV — tetrahydrocannabivarin — is the one cannabinoid you will be pitched specifically for appetite, and it is the one worth understanding rather than dismissing. Unlike THC, it behaves as a CB1 antagonist at the doses studied, which is the opposite of the mechanism described above, and that is a real pharmacological difference rather than marketing.

The evidence, though, is thin. Most of it is preclinical or in vitro. The most cited human result is a small trial published in the journal Cannabis in early 2025, in which obese adults taking a daily oral strip containing 16mg THCV and 20mg CBD lost an average of 4.1kg — about 9lb — over 90 days, alongside reductions in abdominal girth, systolic blood pressure and LDL cholesterol. That is a genuine signal and it is also roughly a tenth of what the GLP-1 trials produced, from one small study, with no established dosing.

So: if you are already on a GLP-1, THCV is not adding anything you need, and it has not been studied alongside these medications at all. If you are looking for an alternative to one, a single small trial is not a substitute for the evidence behind semaglutide or tirzepatide. Be especially wary of THCV products sold on weight-loss claims — that is exactly the framing the FDA has acted against in adjacent categories.

The Vomiting Syndrome That Looks Like a Side Effect

This is the part of the article most worth your attention, because it can lead to the wrong medication being blamed.

Cannabinoid hyperemesis syndrome (CHS) develops in some long-term cannabis users. Chronic use derange and downregulates the endogenous cannabinoid system, and the result — paradoxically, given cannabis's reputation for settling nausea — is rebound vomiting and spasmodic abdominal pain. Its recognised diagnostic features are:

• ▪Severe cyclic vomiting, usually accompanied by abdominal pain
• ▪Symptom onset preceded by at least weekly cannabis use
• ▪Temporary relief of symptoms from hot bathing — an unusual and distinctive feature
• ▪Resolution of symptoms when cannabis use stops

The Inhalation Problem, Properly

Several brands on this page sell vape cartridges, disposables and pre-rolls, and we have kept saying that inhaled products carry risks separate from the appetite question. That deserves more than a passing note, because the specific risk here is not theoretical.

Between June 2019 and February 2020 the United States recorded more than 2,800 hospitalisations and 68 deaths from EVALI — e-cigarette or vaping product use-associated lung injury. The CDC concluded that THC-containing vaping products containing vitamin E acetate were strongly linked to the outbreak. The FDA identified vitamin E acetate in 80% of THC-containing product samples connected to confirmed or probable cases; the CDC found it in 94% of lung-fluid samples from 51 confirmed or probable patients. The agency's recommendation was to avoid THC-containing vaping products, and especially those from informal sources.

Vitamin E acetate was a cutting agent, not an inherent property of cannabis — which is precisely the point. What made those products dangerous was what had been added to them, and the only defence a consumer has against that is verified testing on the actual batch. It is why the certificate-of-analysis question matters far more for an inhaled product than for a gummy.

For a reader taking a GLP-1 the conclusion is straightforward: whatever you decide about cannabinoids and appetite, an inhaled semi-synthetic cannabinoid from an unverified batch is the worst-characterised option available to you, and it is the one we would not touch.

LooperVerse, and why there is no link to it

LooperVerse is in this comparison because you may encounter it, not because we can recommend it. Its catalogue is vape cartridges, disposables and pre-rolls — its Melted and Lifted series, plus a dedicated HHC-P range. There is no CBD line, no broad-spectrum line and no THC-free option; there is nothing on the site that is not an inhaled intoxicant.

We earn commission on many links across this site and we disclose it every time. There is no affiliate link to LooperVerse in this article, because sending a reader taking a prescription medication to buy inhaled semi-synthetic cannabinoids — the product category behind the EVALI outbreak, containing compounds with almost no human safety data — is not something we are willing to do for a commission. If you want a cannabinoid product while on a GLP-1, the THC-free options higher up this page are the ones to look at.

THCa Flower, and the Loophole That Is About to Close

One category on this page deserves explaining because its legality is the least intuitive. THCa flower is sold everywhere online as federally legal hemp, and it is functionally indistinguishable from marijuana once you use it.

The mechanism is chemical. THCa — tetrahydrocannabinolic acid — is the acid form that occurs naturally in the living plant, and it is not intoxicating as it sits. Heat converts it to delta-9 THC through decarboxylation, which is what happens the moment you light it. The 2018 Farm Bill defined hemp by its delta-9 THC concentration on a dry weight basis, so flower that is high in THCa and low in delta-9 tests as compliant hemp in the bag and behaves as marijuana in the lungs. The DEA has taken the position that THCa does not meet the definition of legal hemp, on the basis that Congress directed testing to be done post-decarboxylation — but the market has grown enormously on the other reading.

For a reader taking a GLP-1, the legal argument is beside the point. Smoked THCa flower is smoked THC: the appetite mechanism at the top of this page applies at full strength and with the fastest onset of any route, combustion carries its own well-known harms, and the cannabinoid hyperemesis picture described above is associated with exactly this kind of heavy, regular use.

Flannel Boyz

Flannel Boyz is a small-batch THCa brand selling flower, pre-rolls, rosin and gummies — described on its own site as “100% federally legal, tested, and small-batch craft THCa” — alongside apparel, with products generally in the $30 to $55 range. It verifies age at 21 and notes that some products cannot ship to some states. It publishes certificates of analysis through a footer link rather than from the product page.

There is no CBD-only, broad-spectrum or THC-free product anywhere in the range. As with LooperVerse and TRĒ House, that means there is nothing here that suits someone taking a GLP-1 — and unlike those two, its entire category is the one the November 2026 total-THC standard is aimed squarely at.

The Practical Points

• ▪Tell your prescriber. Not as a confession — because it affects your appetite response, the differential if you develop vomiting, and any sedation you undergo. GLP-1s already complicate anesthesia through delayed gastric emptying.
• ▪Vaping is its own risk category. Inhalation products carry lung risks that gummies and tinctures do not, and the vape market has a poor safety history. If you are choosing a format, that is a real consideration rather than a preference.
• ▪Drug tests. Hemp-derived delta-9 THC products can cause a failed THC test even when the product is Farm Bill compliant. Reputable sellers say so.
• ▪Legality varies by state for intoxicating hemp products, and has been changing quickly. Check your own state rather than assuming federal legality settles it.

CleanAF CBD, Reviewed

If, having read the above, you want CBD products specifically — the non-intoxicating side of this — CleanAF is one of the more established sellers. It has been formulating hemp-derived products in the US for over a decade, assembles at a facility in Clearwater, Florida, and splits its range clearly into broad spectrum (THC-free, black packaging) and full spectrum (contains THC, white packaging). That packaging split is genuinely useful: for a reader avoiding THC, the distinction is made visible rather than buried in a label.

On the things we check: CleanAF states every product is third-party lab tested and publishes a lab results page; it carries the standard FDA disclaimer that its statements have not been evaluated by the FDA and its products are not intended to diagnose, treat, cure or prevent disease; it states its products are hemp-derived and contain less than 0.3% delta-9 THC under the 2018 Farm Bill; and — to its credit — it warns explicitly that ingesting or inhaling hemp-derived delta-9 THC could cause a failed drug test. Shipping is free over $50 and there is a subscribe-and-save option and a stated quality guarantee.

Against that: cannabinoid amounts are not published on the product overview, so you cannot compare potency without digging; the range leans heavily on vapes; and public feedback includes recurring complaints about subscription management and shipping delays — worth knowing before you enrol in a recurring order.

R&R CBD, Compared

If the CleanAF review above left you wanting a product whose label you can actually verify, R&R CBD — also trading as R+R Medicinals — is the better answer, and it is worth setting the two side by side because they differ on precisely the axis this site cares about most.

R&R publishes a Certificate of Analysis for every batch, accessible from its website, with testing carried out by independent laboratories including SC Labs, Botanacor and AgriScience. Those tests cover cannabinoid potency, pesticides, heavy metals and microbial contamination, and reviewers checking them have reported potency accurate to label within about 5% and THC consistently below the 0.3% threshold. It also states cannabinoid amounts plainly — its THC gummies, for instance, are 5mg hemp-derived THC with 10mg CBD per gummy. It sources from USDA-certified organic partner farms, uses CO2 extraction, and publishes a phone number.

The format difference matters for the reason given earlier: R&R sells no vapes, so the inhalation risk does not arise. For a reader on a GLP-1, the THC-free ranges from either company are the relevant ones — the THC products, at both, carry the appetite mechanism described at the top of this page.

One honest limitation on our side: we were unable to load R&R's site directly to confirm current per-product prices, so we are not quoting figures we could not verify. It publishes multi-pack discounts of 10% and 15%.

Summit THC — Good Products, Wrong Category

Summit THC is R&R's sister brand, run by the same Colorado team and acknowledged as such on both sites. It carries the same quality posture: third-party testing through ISO-accredited laboratories including Columbia Labs, published cannabinoid amounts per gummy, the standard FDA disclaimer, free shipping and a stated money-back guarantee. On manufacturing and testing, it is a good operator.

We are still going to tell most readers of this page not to buy it, and the reason is the first section of this article rather than anything wrong with the company. Every Summit product is intoxicating: delta-9 gummies at 15mg per piece ($49.99), delta-8 gummies at 25mg ($54.99), HHC gummies at 25mg, and a THC seltzer ($29.99). That is precisely the category that raises ghrelin and drives appetite through CB1 — the mechanism your GLP-1 is working against.

Soul, Briefly

Soul splits its range the way we would want every brand in this category to: a non-psychoactive CBD line described as “all the calm, none of the high”, and a separately branded intoxicating THC line called Out of Office. For a reader on a GLP-1 that makes the relevant choice obvious without reading a label twice — the CBD side is the one that does not fight your medication.

CBD gummies start at $35, capsules and oil drops at $30, and its sleep line runs to Sleepi gummies at $50 and Sleepi capsules at $30. The intoxicating Out of Office range is priced separately, from $34 for drinks to $84 for high-dose gummies. Products are described as doctor-formulated and third-party lab tested with a certificates-of-analysis page, and the standard FDA disclaimer is present. Shipping is free over $100, unopened returns are accepted within 14 days, and a 30-day guarantee is offered on first orders.

Two caveats. Like CleanAF, Soul does not publish cannabinoid amounts per serving on its product overview — “low, medium, high dose” is a category, not a number — so you cannot compare potency or check it against the CBN evidence without digging into individual pages. And its public review base is small relative to the other brands here.

Aspen Green — Best Quality, No THC-Free Option

Aspen Green is the strongest brand here on every quality measure we check, and the least suitable for this audience. Both things are true at once, which makes it worth explaining rather than just scoring.

On quality: its farms have held USDA Organic certification since 2020, its products are physician-formulated and Colorado-grown, its line undergoes up to eight separate third-party lab tests with COAs readily available, and it publishes exact cannabinoid amounts per serving — Bliss gummies at 100mg CBD+CBDV and 5mg THC+THCV each, Rest at 50mg CBD and 5mg THC, Calm at 25mg CBD and 2.5mg THC. Returns run to 60 days. That is a better disclosure package than anything else on this page.

The problem is in those same numbers. Aspen Green is a full-spectrum brand — its own header reads “Full Spectrum CBD & THC Products” — and every product we found contains THC, from 2.5mg per gummy upward. Unlike R&R and Soul, there is no THC-free line to steer you toward. For a reader taking a GLP-1, that means the whole catalogue sits on the wrong side of the appetite mechanism at the top of this article. It is also priced as a boutique brand: gummies at $59.99 to $89.99 a jar, Bliss oil at $139.99.

The brands here, side by side

Read that table with the first section of this article in mind. The scores reward disclosure and testing; the “THC-free option” column is the one that matters if you are taking a GLP-1.

Canna River deserves a line of its own, because it is the best value on that list for this audience specifically. It publishes certificates of analysis for all its products, tests for potency and contaminants including heavy metals, microbes and pesticides, and — critically — sells a broad-spectrum, THC-free range in four targeted formulas: classic CBD, calm (CBD+CBG+CBN), sleep (CBD+CBN) and pain (CBD+CBG). Naming the cannabinoid combination in each formula is more useful than a “full spectrum” label, and its pricing is at the low end for the potency offered. One practical note: its original domain now redirects to River Botanicals, so do not be alarmed if the name on the site differs from the one you searched for.

Joy Organics is the other one worth naming for this audience, and on the criteria that matter here it is the strongest option on the list. Its THC-free broad-spectrum range is the core product line rather than a side option, it holds USDA organic certification, it publishes per-serving amounts plainly — tinctures at 30mg, 45mg or 75mg of broad-spectrum CBD per serving, gummies at 10mg or 25mg each — and every bottle carries a QR code linking directly to that batch's lab report. Independent testing has verified its THC-free claims. Pricing is mid-premium rather than cheap, with 20% off on subscription.

If you want a cannabinoid product and you are taking a GLP-1, this is the shortest path to one that will not work against your medication: a THC-free line, an organic certification, stated doses, and a lab report you can reach from the bottle in your hand.

Cheech & Chong's belongs in the same bracket as Summit: a competent operator selling the wrong category for this audience. Its testing posture is genuinely good — every batch third-party tested for potency, purity, heavy metals, pesticides, microbials and contaminants, with the COA viewable on each product page — and it offers a full refund with, in its words, “no hoops, no hassle”. Doses are stated: gummies from 3 to 20mg, drinks 10 to 40mg, shots 10 to 25mg.

But those are all THC doses. The range spans delta-9 edibles, THCa flower and pre-rolls, vapes and beverages, all intoxicating, with only a small separate CBD tincture line that is THC-free. Between the appetite mechanism at the top of this page and the inhalation risk that applies to flower and vapes, there is very little here we would point a GLP-1 patient toward — the tinctures aside.

Redeem Therapeutics is the budget option, and it solves the labelling problem better than anyone here. Rather than expecting you to decode “full spectrum” versus “broad spectrum”, it marks products plainly as either THC-free or “+THC” — which is exactly the distinction that matters if you are taking a GLP-1, stated in the words a normal person would use. Every batch is third-party tested with traceable, published lab results, the FDA disclaimer is present, and its gummies run $12.99 to $43.99, the lowest prices on this list. Its sleep gummies combine CBN with melatonin and botanicals.

It publishes less per-serving detail on its overview pages than R&R or Joy Organics do, so you will need the individual product page or the COA for exact amounts. But for a reader who simply wants a cheap, clearly labelled, THC-free option, this is the most straightforward route on this page.

Vena CBD is the first brand on this list built primarily around THC drinks, and that shapes how a GLP-1 patient should read it. Its labelling is good. Every product states both cannabinoids in milligrams per serving — Xtra Bliss gummies at 10mg THC and 10mg CBD, Cloud 9 Mood at 5mg THC and 50mg CBD with saffron, Lights Out at 5mg THC and 50mg CBD with melatonin, the Happy Tonix seltzers at 2mg THC and 2mg CBD or 10mg THC and 5mg CBD per 40-calorie can. Testing is doubled: Vena states every product is third-party tested twice, once on the hemp distillate before production and again on the finished product, covering potency and pesticide screening. Its refund terms are among the more concrete here — a full refund of the purchase price within 30 days of delivery, with the customer covering return shipping — and it publishes a support phone number, an email address and staffed hours, and ships to all 50 states. There are no vapes and no flower.

The catch is the column that matters. Vena states that “all of our CBD capsules are completely THC-free” — and those capsules are the entire THC-free range: Rise + Shine at 25mg CBD and Restful Night at 15mg CBD with melatonin, both $39.95, or $29.96 on subscription. Every gummy contains THC. The full-spectrum tincture is 50mg CBD to 2mg THC per serving. Every seltzer is a THC drink. If you are taking a GLP-1, those two capsules are the products on this site for you, and the rest of the catalogue is not.

The seltzers deserve their own note, because they are aimed squarely at people cutting down on alcohol — 40 calories a can, 15 for the “Skinny Mocktails”. That overlap is real: GLP-1 medications do appear to reduce alcohol craving for many people. But swapping alcohol for THC trades one appetite problem for another, and the mechanism described at the top of this page runs directly against what you are taking the medication to do. Sparkling water is the boring answer and the better one. Worth knowing too that the whole Happy Tonix line and the full-spectrum tincture were showing sold out when we checked.

CBDfx is the largest and longest-running operator on this list, and it does several things better than anyone else here. Its THC-free range is a proper broad-spectrum line rather than an afterthought, marked ND-THC — non-detectable THC — across gummies, tinctures, capsules and topicals. It states that lab reports come from independent, ISO 17025-certified laboratories and that every product is backed by a certificate of analysis. And it is the only brand on this page with a named medical advisory board: a dermatologist, a pharmacist, an internal medicine physician and a veterinarian, listed with their credentials rather than as an anonymous “expert team”.

Its returns are the most generous here by some distance. CBDfx offers a 60-day guarantee that explicitly accepts opened products — “items containing a reasonable amount of the unused product” — where most brands require an unopened box. Shipping charges are not refunded, and a 25% restocking fee applies if a product returned as defective shows signs of having been dropped.

Two caveats. The first is dosing: CBDfx's gummies are strong, at 50mg, 100mg or 200mg of broad-spectrum CBD per gummy against 10–25mg at Joy Organics. That is not automatically better, and if you are new to CBD it is a lot per serving — check the per-gummy figure rather than the jar total. The second is that CBDfx does not link a batch report from the product page. You reach lab reports through a central page rather than by scanning the bottle in your hand, which is a step behind R&R and Joy Organics on the one thing that lets you verify what you actually bought. Note also that its range includes a substantial vape and vape-juice line, and that it does not ship to Idaho.

Tillmans Tranquils is worth a paragraph mainly for its sleep range, which is the most precisely specified on this page. Its Blackberry sleep gummies state 20mg CBD, 10mg CBN and 5mg THC per gummy and describe that as a 4:2:1 ratio; more usefully for anyone on a GLP-1, it also sells a genuinely THC-free pair — “0 THC Melatonin Gummies with CBD & CBN” and “CBN Sleep Mints - No THC” at 10mg CBD and 10mg CBN per mint. Naming the THC content in the product title is a good habit, and the numbers line up with what our sleep guide covers about the CBN evidence.

The rest is harder to recommend. The catalogue is overwhelmingly intoxicating — THC gummies, mints, drinks, cookies and syrups, including 420mg delta-9 syrups — and it includes a delta-8 line, a semi-synthetic cannabinoid we would steer clear of for the same reasons set out in the Summit section above. Lab reports are grouped by product category rather than linked from the bottle. And the published return policy is unfinished Shopify boilerplate: it instructs you to send returns to “[INSERT RETURN ADDRESS]”, carries an EU cooling-off clause for a US-only brand, and excludes “perishable goods (such as food…)” and personal care goods from returns — which is most of what it sells. Assume gummies are non-returnable.

Koi CBD gets the mechanics right in a way that is genuinely useful, and then sells a catalogue we would mostly steer you away from. On the mechanics: its lab results are searchable by the unique batch number printed on the product you are holding, which is the correct way to do this and better than a central reports page; it offers a 30-day money-back guarantee — “if you're unhappy, just let us know within 30 days of receiving your delivery, and we'll give you a refund”; and it carries the FDA disclaimer plainly. Best of all, it lets you browse by strength — Zero-THC, Low-THC, Medium-THC, High-THC — which is the single most useful navigation feature on any site in this comparison for a reader taking a GLP-1. Filter to Zero-THC and the appetite problem simply disappears from your results.

The catch is what fills the rest of the shop. Koi's range runs to delta-8, delta-9, THC-A flower, pre-rolls and vapes, and THC-P — a very potent semi-synthetic cannabinoid. Two cautions there. Inhaled products carry their own risks entirely separate from the appetite question. And the semi-synthetic cannabinoids sit in contested legal territory: the DEA concluded in 2023 that delta-8 and delta-9 THC-O acetate are Schedule I controlled substances, on the reasoning that they do not occur naturally in the cannabis plant and can only be produced synthetically, so they are not hemp under the 2018 Farm Bill. That reasoning has been litigated since and does not automatically extend to every novel cannabinoid, but it tells you how unsettled the category is. Use the Zero-THC filter and ignore the rest.

Medterra is the third brand here we would put in front of a GLP-1 reader without qualification, and it earns that on labelling. Rather than expecting you to decode “full spectrum”, it states the actual THC content of every gummy in milligrams — Deep Sleep and Max Relief at 2mg THC, Daily Delight and Mood Boost at 5mg, Extra Delight at 10mg — and badges the products that contain none as THC-Free. Nobody else on this page tells you the THC dose that plainly across the whole range.

It also gives you two separate routes to zero THC rather than one. Its isolate gummies — Sleep Tight and Focus, 25mg CBD, around $34.49 — are pure CBD with no other cannabinoids at all, and its broad-spectrum Calm gummies are 25mg CBD at 0% THC for around $22.49, making them among the better-value THC-free options here. Certificates of analysis are batch-level: Medterra states each product has a corresponding certificate leading to a dedicated page covering that batch, its ingredient profile and quality control methods. New customers get a 30-day risk-free trial that accepts opened product, with a general 30-day returns policy for unopened items after that.

One caveat, and it is to Medterra's credit that we can even report it: the company states plainly that its products “are not tested for herbicides such as glyphosate, because, under the Kentucky Department of Agriculture's organic farming practice, we already avoid using any chemicals during the growing and extraction process”. Disclosing a testing gap is more honest than most brands manage. But “we do not use it, so we do not test for it” is precisely the assumption that testing exists to verify, and if a glyphosate screen matters to you, this is the brand where you will not get one.

Five is the most instructive entry on this list, because it is owned by the same company as Medterra and is its exact mirror image. Where Medterra prints THC content in milligrams so you can avoid it, Five has repositioned entirely around THC — the shop is THC gummies, THC drinks, THC drops, THC capsules and THC edibles, browsed by strength: 2mg microdose, 5mg daily dose, 10mg high dose, 15mg quick hits. There is no broad-spectrum line, no isolate line, and no THC-free option anywhere on the site. One parent company, two brands, opposite answers to the only question that matters here.

On its own terms Five is competent. Dose tiering from 2mg upward is genuinely good practice and better than the brands that sell one strength; it publishes certificates of analysis carrying batch information, ingredient profiles and quality control methods; the return policy is 30 days; and it is unusually clear that although hemp-derived delta-9 is federally legal under the 2018 Farm Bill, many states have their own laws and shipping depends on yours. But for a reader taking a GLP-1, competence in a category built entirely on the appetite mechanism described at the top of this page is not a recommendation. If you want this company's products, buy the Medterra ones.

TRĒ House scores lowest on this page, and it is not close. There is no broad-spectrum line, no isolate line and no THC-free product anywhere — but that is the least of it. The doses are the problem. Its delta-8 gummies are 100mg per gummy, 2,000mg per bottle. For scale, the THC-containing gummies elsewhere in this comparison run 2mg to 10mg per piece. A hundred milligrams in a single sweet is not a strength tier; it is an order of magnitude beyond the rest of this list.

The rest of the range compounds it: delta-8, delta-9, delta-10, HHC and THC-P across gummies, vape cartridges, pre-rolls and rolling papers. THC-P in particular is among the most potent cannabinoids sold in this market. The inhaled products carry risks entirely separate from the appetite question, and the semi-synthetic cannabinoids sit in the same contested legal territory described in the Koi section above. The house style is not subtle about any of it — product copy promises “getting ripped” and “long, mind-expanding sessions”.

To be fair on the mechanics: TRĒ House publishes lab reports organised by named product, states its cannabinoid content per gummy, and warns clearly that products are 21+, may cause psychotropic effects, and should not be used before driving. Those are the right disclosures. They simply do not change the answer for anyone taking a GLP-1, which is that there is nothing on this site for you.

BATCH does a lot right and then trips on the one column that matters here. On the right side of the ledger: no vapes and no flower anywhere in the range, per-serving amounts stated plainly across gummies, tinctures and softgels, a 30-day money-back guarantee with free returns, GMP-certified manufacturing, hemp grown on a named Wisconsin farm, and founders who are actual chemical engineers rather than a marketing team. Its subscription runs from 20% off and deepens over time, with the ability to pause or cancel.

The catch is that BATCH's clearly labelled “THC Free” broad-spectrum products are its pet products — the pet tincture and the pet treats. Every human product we checked is full spectrum: the 25mg CBD gummies, the CBD softgels, and the Dream, Calm and Clarity tinctures. BATCH describes the human range as containing “trace amounts of THC, but not enough to cause any intoxication”, which is a fair description of a full-spectrum extract and is not the same problem as a 10mg THC gummy. Trace THC in a full-spectrum CBD product is primarily a drug-test question rather than an appetite one.

But if your reason for wanting THC-free is the appetite mechanism at the top of this page, and you would rather not think about the margin, BATCH is a brand where the option exists for your dog and not for you. Its separate Recreation line of THC gummies and seltzers is the part that genuinely works against a GLP-1, and that one is clearly labelled.

Extract Labs is the strongest manufacturing and traceability story on this page, and traceability is the thing that actually protects you in an unregulated category. It was founded in 2016 by Craig Henderson, an army combat veteran, and it is vertically integrated in a way almost nobody else here is: it operates its own hemp extraction lab in Colorado and keeps every step of production in-house rather than buying distillate and filling bottles. Products are made in a cGMP-certified facility.

The part that matters most in practice is how you check a batch. Extract Labs prints the batch number on the product label and maintains a searchable certificate-of-analysis database on its site, so you can look up the report for the specific bottle in your hand rather than a representative sample of something similar. Only Koi matches that on this page, and it is the single most useful thing a cannabinoid company can offer.

It sells a THC-free line alongside full-spectrum products — its organic THC-free daily support oil is labelled as such in the product name — plus gummies, capsules, topicals, concentrates, isolate powders and vape cartridges. The vape range carries the same caution as everywhere else on this page. One further mark in its favour: it publishes a plain-English explainer of the November 2026 total-THC rule and the 0.4mg-per-container cap on its own site, which is an unusually straight thing for a hemp company to do about legislation that will remove most of its own category.

FOCL does two things better than almost anyone here. The first is that it defines its terms instead of assuming you know them: its broad-spectrum products state that “Broad Spectrum hemp comes from an extract that does not contain trace amounts of THC” and are labelled THC-free on the product. After reading a lot of packaging that expects you to infer the difference, being told it plainly is worth something. Its Daily Calm gummies are 25mg of broad-spectrum hemp per gummy, 750mg a jar, and there are THC-free options across sleep gummies, sleep drops, brain gummies and topicals. There are no vapes and no flower anywhere in the range.

The second is the guarantee, which is the most generous on this page. FOCL offers a 60-day satisfaction guarantee and explicitly accepts “unused or empty bottles” — you can finish the product, decide it did nothing, and still ask for your money back. Subscription customers who cancel within 60 days without the bottles are eligible for a 50% one-month refund. Customers pay return shipping and a return authorisation number is required. Against that: FOCL links third-party test results but does not name the laboratory, and we could not confirm whether reports are tied to your specific batch — which is the one place R&R, Koi and Extract Labs are ahead of it.

Frequently Asked Questions

Where to Go Next

• ▪GLP-1 side effects guide — what nausea and vomiting normally look like on treatment
• ▪Sleep and GLP-1 weight loss — what the CBN evidence actually supports
• ▪Kratom and GLP-1 medications — the other “natural” category with a real interaction problem