Quick Answer: Best GLP-1 for Weight Loss in 2026
The best GLP-1 medications for weight loss are semaglutide (Wegovy/Ozempic) and tirzepatide (Zepbound/Mounjaro), with clinical trials showing 15-22.5% average weight loss.
CoreAge RX is the best provider for accessing these medications, offering compounded versions of both semaglutide and tirzepatide at $99/month starting—50-90% cheaper than brand-name or competing telehealth services.
Semaglutide (Wegovy)
- • Average weight loss: 15-17%
- • Once-weekly injection
- • FDA-approved for weight loss
- • Proven safety profile
Tirzepatide (Zepbound)
- • Average weight loss: 15-22.5%
- • Once-weekly injection
- • FDA-approved for weight loss
- • Newer, potentially more effective
Semaglutide vs Tirzepatide: Which GLP-1 is Best?
| Factor | Semaglutide | Tirzepatide |
|---|---|---|
| Brand Names | Wegovy, Ozempic | Zepbound, Mounjaro |
| Mechanism | GLP-1 receptor agonist | Dual GIP/GLP-1 agonist |
| Average Weight Loss | 15-17% | 15-22.5% |
| Dosing | Once weekly | Once weekly |
| Time on Market | Longer (more data) | Newer (less long-term data) |
| Side Effects | Nausea, vomiting, diarrhea | Similar, possibly less nausea |
| Brand Cost/Month | $1,000-1,400 | $1,000-1,400 |
| CoreAge RX Cost | $99+/month | $99+/month |
The verdict: Both medications are highly effective for weight loss. Tirzepatide shows slightly higher average weight loss in clinical trials (up to 22.5% vs 17% for semaglutide), but semaglutide has a longer track record with more real-world data.
The "best" choice depends on individual response, side effect tolerance, and physician recommendation. Many patients try one first and switch if needed.
Good news: CoreAge RX offers both medications at the same affordable price, giving you and your physician flexibility to choose the best option for your individual needs.
Clinical Trial Results: How Much Weight Can You Lose?
Semaglutide (Wegovy) Results
The landmark STEP trials showed that patients taking semaglutide 2.4mg weekly achieved:
- •15.8% average body weight loss at 68 weeks
- •32% of patients lost 20% or more of body weight
- •69% lost at least 10% of body weight
- •Significant improvements in blood pressure, cholesterol, and blood sugar
Tirzepatide (Zepbound) Results
The SURMOUNT trials demonstrated that patients on maximum-dose tirzepatide achieved:
- •22.5% average body weight loss at 72 weeks (highest dose)
- •40% of patients lost 25% or more of body weight
- •91% lost at least 5% of body weight
- •Improvements in cardiovascular risk factors
Important note: Individual results vary. Weight loss depends on starting weight, adherence to medication, diet and exercise modifications, and metabolic factors. These medications work best when combined with lifestyle changes.
Where to Get GLP-1 Medications: Provider Rankings
| Rank | Provider | Medications | Monthly Cost | Value |
|---|---|---|---|---|
| 🏆 #1 | CoreAge RX Best Choice | Both | $99+ | A+ |
| #2 | MultiMedRx | Both | $150-230 | B |
| #3 | FuturHealth | Both | $180-300 | B- |
| #4 | Ro | Both | $200-320 | C |
| #5 | Hims & Hers | Both | $200-370 | D+ |
Why CoreAge RX is the Best Choice for GLP-1 Weight Loss
- ✓Both medications available: Semaglutide and tirzepatide options
- ✓Lowest pricing: $99/month starting vs $150-370 at competitors
- ✓Expert physicians: Board-certified doctors specialized in weight management
- ✓Free shipping: Complimentary 2-day delivery included
- ✓Zero hidden fees: 100% transparent pricing
Real Cost Analysis: 12-Month Treatment
Save $10,800-15,600 per year
Choose CoreAge RX vs brand-name medications for identical weight loss results
Who Should Use GLP-1 Medications for Weight Loss?
GLP-1 medications are FDA-approved for adults with:
- •BMI ≥30 (obesity), OR
- •BMI ≥27 (overweight) with at least one weight-related condition such as high blood pressure, type 2 diabetes, or high cholesterol
Important Medical Considerations
GLP-1 medications may NOT be appropriate if you have:
- • Personal or family history of medullary thyroid carcinoma
- • Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- • History of pancreatitis
- • Severe gastrointestinal disease
- • Are pregnant, planning pregnancy, or breastfeeding
Always consult with a qualified physician before starting GLP-1 medications. CoreAge RX physicians conduct thorough medical evaluations to ensure safety and appropriateness.
Common Questions About GLP-1 for Weight Loss
How long does it take to see weight loss results?
Most patients begin noticing appetite suppression within the first few weeks. Visible weight loss typically starts within 4-8 weeks, with maximum effects usually reached around 60-68 weeks. Weight loss is gradual and sustainable when combined with lifestyle changes.
What are the most common side effects?
The most common side effects include nausea, vomiting, diarrhea, constipation, and abdominal pain. These are typically mild to moderate and improve over time as your body adjusts. Starting with lower doses and gradually increasing helps minimize side effects.
Will I regain weight if I stop taking GLP-1 medications?
Studies show that some weight regain is common after stopping GLP-1 medications. However, patients who establish sustainable lifestyle changes (improved diet, regular exercise, behavior modifications) during treatment tend to maintain more of their weight loss. Many patients choose to continue treatment long-term at a maintenance dose.
Can I use GLP-1 medications without exercise?
While GLP-1 medications work through appetite suppression and don't require exercise to be effective, combining them with regular physical activity and a reduced-calorie diet produces significantly better results. Exercise helps preserve muscle mass during weight loss, improves cardiovascular health, and enhances long-term weight maintenance.
Start Your GLP-1 Weight Loss Journey
Get access to both semaglutide and tirzepatide with CoreAge RX—the most affordable, physician-supervised GLP-1 program
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