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Yucca Health at a Glance
- What it is
- Cheapest on a six-month plan, with the smallest month-to-month penalty here and eligibility criteria that actually match the approved indications
- Medication type
- Compounded only
- Medications offered
- Compounded semaglutide
- Compounded tirzepatide (GLP-1/GIP)
- NAD+ and sermorelin, sold separately from the weight programme
- Pricing
- Semaglutide $125/mo on 6 months or $146 monthly; tirzepatide $225 or $258 — no membership fee
- Insurance
- Cash-pay. Compounded medication is never covered by insurance, and Yucca states no insurance is required.
- Date reviewed
- August 7, 2026
How we scored it
Scores follow the published rubric in our provider comparison methodology.
Medical Disclaimer
We're not doctors, and this review is not medical advice. GLP-1 medications are prescription-only and require evaluation by a licensed healthcare provider. What works for one person may not work for another, and only a clinician who knows your history can determine whether a medication is appropriate for you. See our full medical disclaimer.
What Is Yucca Health?
Yucca competes on price and, unusually, does not punish you for declining to commit. Compounded semaglutide is $125/month on a six-month plan ($750 total) or $146/month month-to-month. Compounded tirzepatide is $225/month on six months ($1,350 total) or $258 month-to-month. There is no separate membership fee, so those figures are close to what you actually pay.
That month-to-month gap is the quietly remarkable part. Yucca charges about 17% more to buy monthly. Across this comparison, providers routinely charge 50% to 100% more for the same medication without a commitment — TrimRx at $174 committed against $299 monthly, Trimi at $125 against $235. Paying a small premium to keep your options open is a genuinely different proposition from paying double.
Yucca also publishes its eligibility criteria, and they are the right ones: a BMI of 30 or above, or 27 or above with a weight-related condition, with those above 25 possibly qualifying depending on medical history as judged by a licensed provider. That mirrors the FDA-approved indications for these medications rather than stretching them, and it stands in sharp contrast to providers advertising minimum BMIs in the low twenties.
Its FDA disclosure is equally direct: "Compounded medications are prepared by licensed U.S. pharmacies, are not FDA-approved, and do not undergo FDA review." Licensed providers cover all 50 states, and free expedited two-day UPS shipping is included.
How the Program Works
- Consultation process
- Online intake and eligibility check reviewed by a licensed provider. Yucca states no insurance is required, and licensed providers cover all 50 states.
- Eligibility
- Published and appropriately conservative: BMI of 30 or above, or 27 or above with a weight-related condition. Those with a BMI above 25 may qualify depending on medical history, as determined by a licensed provider. That aligns with the approved indications for these medications.
- Provider involvement
- Licensed providers in all 50 states review and prescribe, with ongoing care-team support through a patient portal. Yucca is a lean, medication-focused service rather than a coaching programme.
- Lab requirements
- Not published as a universal requirement.
- Pharmacy fulfillment
- Filled by US licensed pharmacies. Yucca does not publicly name an exclusive compounding partner.
- Shipping frequency
- Free expedited two-day shipping via UPS, on a monthly cycle within the plan purchased.
- Support services
- Patient portal and ongoing care-team support. No coaching curriculum or app — this is a medication service rather than a programme.
Yucca Health Pricing
- Membership fee
- None. The medication price is the whole price, including shipping.
- Medication fee
- Compounded semaglutide at $125/month on a six-month plan ($750 paid upfront) or $146/month month-to-month. Compounded tirzepatide at $225/month on six months ($1,350 upfront) or $258/month month-to-month. NAD+ and sermorelin start at $158/month on three-month plans.
- Cancellation policy
- Not published in detail. Since plan commitments are paid upfront, establish what happens if you stop partway through a six-month plan before you pay.
- Refund policy
- Not published. Compounded medication is not returnable once dispensed.
- Insurance
- Cash-pay. Compounded medication is never covered by insurance, and Yucca states no insurance is required.
- HSA / FSA
- Not published. Confirm with your plan administrator.
Pricing details worth knowing
- The month-to-month premium is only about 17%. Most providers here charge 50–100% more to avoid a commitment, which makes Yucca unusually fair if you want flexibility.
- Plan commitments are paid upfront — $750 for six months of semaglutide, $1,350 for tirzepatide.
- Ondra Health publishes a lower semaglutide rate at $96/month, but that needs a twelve-month prepayment. On a six-month horizon Yucca is the cheapest here.
- Free two-day UPS shipping is included rather than added.
- Published eligibility criteria match the FDA-approved indications, which is not true of every competitor.
Prices change. Every figure above was taken from Yucca Health's published pages or the named sources at the bottom of this review, as of August 7, 2026. Telehealth pricing in this market changes frequently, and promotional rates expire. Confirm your actual cost at checkout before enrolling.
Pros and Cons
Pros
- Cheapest compounded semaglutide on a six-month commitment at $125/month
- Only about 17% more to buy month-to-month — by far the smallest commitment penalty here
- Published eligibility criteria that match the FDA-approved indications rather than stretching them
- No membership fee; free expedited two-day UPS shipping included
- Licensed providers across all 50 states
- A plain, accurate statement that its compounded medication is not FDA-approved and does not undergo FDA review
Cons
- Plan commitments are paid upfront — $750 or $1,350 in one go
- No published cancellation or refund terms against those upfront payments
- Does not name its compounding pharmacy
- No lab work required
- A lean service — no coaching, app or programme content if you want that
- Ondra Health is cheaper still at $96/month if you will commit twelve months
Who Yucca Health May Be Best For
Anyone who wants a low price without locking into a year — the month-to-month rate here is the most reasonable in this comparison
People who want the medication and nothing else, without paying for coaching they will not use
Buyers who want to see eligibility criteria stated honestly before starting an intake
Limitations
Six-month plans are paid upfront and the refund position is not published. Establish it in writing before committing $750 or $1,350.
If you are willing to commit a full year, Ondra Health publishes $96/month and names all five of its compounding pharmacies.
No bloodwork is required. If you have relevant medical history, raise it explicitly at intake.
Compounded medication carries the regulatory caveats described below, including the FDA proposal published in May 2026.
About Compounded GLP-1s
The FDA declared the tirzepatide shortage resolved in December 2024 and the semaglutide shortage resolved in February 2025, which ended the window for compounding pharmacies to make large volumes of copies of those drugs (503A pharmacies had until April 22, 2025; 503B outsourcing facilities until May 22, 2025). Many telehealth companies continue to offer compounded GLP-1s prescribed for an individual patient — often as a personalized dose, a microdose, or a formulation combined with a vitamin such as B12 or B6. That practice sits in a contested legal area, and the FDA has continued to act. In a Federal Register notice published on May 1, 2026, the FDA proposed not to include semaglutide, tirzepatide or liraglutide on the 503B bulks list, saying it had not identified sufficient evidence of a clinical need for outsourcing facilities to compound them from bulk substances; the comment period was extended to July 30, 2026. Separately, in February 2026 the FDA issued warning letters to 30 telehealth companies over false or misleading claims about compounded GLP-1s, and it has continued: a further round dated 8 June 2026 — 25 warning letters, posted publicly on 16 June 2026 — reached companies including Medica Weight Loss, FITISH and Roen Health (RoenRx), again over false or misleading claims about compounded semaglutide and tirzepatide that the FDA said made the products misbranded under sections 502(a) and 502(bb) of the FD&C Act. The claims cited included suggesting the products were FDA-approved, implying equivalence to Ozempic, Wegovy, Mounjaro or Zepbound, and asserting the "same active ingredient" or "same results" as the approved drugs. Compounded medications are not FDA-approved, which means they have not gone through the same review as the brand-name products.
None of that is specific to Yucca Health — it applies to every provider offering compounded medication. We cover the trade-offs in detail in our guide to brand-name versus compounded GLP-1s.
Alternatives to Yucca Health
Ondra Health
Cheaper at $96/mo on twelve months, flat at every dose, with all five pharmacies named
Read review →Trimi
$99/mo annually with named pharmacies and a published medical director
Read review →Sunlight
Names six pharmacies, includes lab work, and ships refrigerated
Read review →vs. CoreAge RX, our top-rated platform
Across the platforms we've reviewed, CoreAge RX remains our highest-rated option for cash-pay patients, with compounded semaglutide from $99/month and tirzepatide from $149/month including free two-day shipping. Whether it beats Yucca Health for you depends on the things this review has covered — insurance, medication type, and how much support you actually want.
Frequently Asked Questions
How much does Yucca Health cost?
Compounded semaglutide is $125/month on a six-month plan ($750 paid upfront) or $146/month buying month to month. Compounded tirzepatide is $225/month on six months ($1,350 upfront) or $258/month monthly. There is no membership fee and free two-day UPS shipping is included, so those figures are close to your real total. NAD+ and sermorelin are sold separately from $158/month on three-month plans.
Is it worth committing to six months at Yucca?
Less than at most providers, which is a compliment to Yucca. The saving is about 17% — $125 against $146 for semaglutide. Compare that with providers who charge 50% to 100% more for month-to-month, and the case for locking in $750 upfront is much weaker here. If you are unsure whether you will tolerate the medication, the monthly rate is genuinely affordable, which is unusual.
Who is eligible for Yucca Health?
Yucca publishes criteria that match the approved indications: a BMI of 30 or above, or 27 or above with a weight-related condition, with those above 25 possibly qualifying depending on medical history as determined by a licensed provider. That is worth crediting — several providers in this comparison advertise minimum BMIs well below the approved thresholds, and one states a floor of 20.
Is Yucca cheaper than Ondra Health?
It depends on how long you will commit. Ondra publishes $96/month for compounded semaglutide, but that rate needs a twelve-month prepayment. Yucca is $125/month on six months and $146 month-to-month. Over a full year Ondra is cheaper; over six months, or if you want the flexibility to stop, Yucca costs less overall and asks for a smaller upfront payment.
Who should not use Yucca Health?
Anyone who wants coaching, an app or a structured programme — this is a lean medication service by design. Anyone who wants lab work before starting, or who needs published refund terms before paying upfront. Separately, GLP-1 medications are not appropriate if you have a personal or family history of medullary thyroid carcinoma or MEN 2, if you are pregnant or trying to conceive, or if you have had pancreatitis. Common side effects include nausea, vomiting, diarrhoea and constipation during titration. A licensed clinician who knows your history should decide.
The Verdict
Yucca publishes compounded semaglutide at $125/month on a six-month plan and $146 month-to-month, and tirzepatide at $225 and $258 respectively, with no membership fee. Two things stand out beyond the price: the gap between committing and not committing is only about 17%, where most competitors double it — and its published eligibility criteria mirror the FDA-approved indications rather than stretching them.
Opens Yucca Health's official site · Verify current pricing there
Compare Every Provider Side by Side
See how Yucca Health stacks up against every platform we've reviewed on price, medication type, and what's actually included.
How We Researched This Review
We compiled this review on August 7, 2026 from Yucca Health's own published pages plus independent reporting. We have not signed up for this service ourselves, and we say so rather than implying firsthand testing. Where Yucca Health does not publish a detail — refund terms, lab requirements, pharmacy partners — we've said that plainly instead of guessing.
Sources
- tryyucca.com — compounded semaglutide at $125/month on a six-month plan ($750 total) and $146/month month-to-month; compounded tirzepatide at $225/month on six months ($1,350 total) and $258/month monthly; NAD+ and sermorelin from $158/month on three-month plans; no membership fee; free expedited two-day UPS shipping; licensed providers in all 50 states; patient portal and care-team support (checked August 7, 2026)
- tryyucca.com — published eligibility criteria of BMI 30+, or 27+ with a weight-related condition, with BMI above 25 possibly qualifying depending on medical history as determined by a licensed provider
- tryyucca.com FDA disclaimer — "Compounded medications are prepared by licensed U.S. pharmacies, are not FDA-approved, and do not undergo FDA review."
- Comparison pricing from Ondra Health ($96/month on a twelve-month plan), as covered in its own review on this site
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