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SynergyRX at a Glance
- What it is
- Names its prescribers with NPI numbers and four pharmacies with phone numbers — then publishes no GLP-1 price and claims outcomes it does not source
- Medication type
- Brand-name and compounded
- Medications offered
- Compounded semaglutide — injection and oral dissolving tablet
- Compounded tirzepatide — injection and oral
- Brand-name Wegovy, Ozempic and Mounjaro, where clinically appropriate
- Longevity injections: NAD+, sermorelin, glutathione, PT-141 and B12
- Pricing
- GLP-1 prices not published on the site; third parties report compounded semaglutide from $199/mo and tirzepatide from $349/mo
- Insurance
- Not addressed. This is a cash-pay service, and compounded medication is not covered by insurance in any case.
- Date reviewed
- August 7, 2026
How we scored it
Scores follow the published rubric in our provider comparison methodology.
Medical Disclaimer
We're not doctors, and this review is not medical advice. GLP-1 medications are prescription-only and require evaluation by a licensed healthcare provider. What works for one person may not work for another, and only a clinician who knows your history can determine whether a medication is appropriate for you. See our full medical disclaimer.
What Is SynergyRX?
SynergyRX is a nationwide cash-pay telehealth service selling compounded and brand-name GLP-1s, launched in December 2025. Two things about it are genuinely better than the field, and two are worse, and they sit on the same page.
The good part first, because it is unusual enough to lead with. SynergyRX names its medical group and its prescribers — Lion MD, led by Dr Ana Lisa Carr MD (NPI 1689841744) and Dr Kelly Tenbrink MD (NPI 1346482684) — with NPI numbers you can look up in the national registry yourself. It then names four partner pharmacies with phone numbers and websites: Belmar Pharmacy, Strive Pharmacy, Epiq Scripts and Casa Pharma Rx. Across more than ninety providers we have reviewed, almost none name a single compounding pharmacy. Naming four, with contact details, and naming the prescribers with verifiable identifiers, is the most complete supply-chain disclosure we have seen.
Its eligibility criteria are also stated properly: a BMI of 30 or higher, or 27 or higher with at least one weight-related condition such as high blood pressure, high cholesterol or pre-diabetes. That matches the FDA-approved indications, and it is markedly more conservative than the BMI-22 floors some competitors advertise.
Now the other half. The same homepage headlines "The Proven Way to lose 15% of your body weight fast!" and states that "On average, patients in the SynergyRx program lose 15-20% of their body weight", with a breakdown claiming 85% of patients lose 10% of body weight, 60% lose 15% and 50% lose 20%. Those are presented as SynergyRX programme results and are not sourced anywhere. They also sit oddly beside the company's own FAQ, which says something much more defensible — that "clinical studies have shown average weight loss of 10–20% of body weight over 6–12 months". One of those is a careful statement about the drug class; the other is an unsourced claim about this company's patients.
And for a GLP-1 company, it does not publish GLP-1 prices. The pricing tiles on its homepage cover longevity products only — NAD+, sermorelin, glutathione and PT-141 at $275, B12 at $109. Third-party reviewers report compounded semaglutide from $199/month and tirzepatide from $349/month, scaling with dose, and brand-name Wegovy and Mounjaro at $947/month. We could not verify any of those from SynergyRX itself.
How the Program Works
- Consultation process
- An online medical intake form, then a telehealth consultation with a licensed provider, with review reported at 24 to 48 hours. Monthly check-ins and messaging access are described as included.
- Eligibility
- Stated as a BMI of 30 or higher, or 27 or higher with at least one weight-related condition such as high blood pressure, high cholesterol or pre-diabetes — matching the FDA-approved indications for the brand-name products. A provider reviews your history to decide.
- Provider involvement
- Prescribing runs through Lion MD, named on the site as a nationwide medical group led by Dr Ana Lisa Carr MD (NPI 1689841744) and Dr Kelly Tenbrink MD (NPI 1346482684). Both NPI numbers can be checked in the NPPES registry. SynergyRX states plainly that it is not a medical provider and does not control the practice of medicine by the independent medical groups on the platform.
- Lab requirements
- Not published. Nothing states whether bloodwork is required before or during treatment, or what it costs.
- Pharmacy fulfillment
- Four partner pharmacies are named on the site with phone numbers and websites: Belmar Pharmacy, Strive Pharmacy, Epiq Scripts and Casa Pharma Rx. SynergyRX states it "does not manufacture, dispense, or control the formulation of any medications prescribed", which is the correct disclosure. It does not state which of the four fills a given prescription, or their 503A versus 503B status — worth asking, since you now have four phone numbers with which to ask.
- Shipping frequency
- Free shipping is advertised, described as discreet, with delivery reported at five to seven days after provider approval.
- Support services
- Monthly check-ins and messaging access, with 24/7 medical support advertised. A separate longevity and sexual health range is sold on the same account.
SynergyRX Pricing
- Membership fee
- None published. A "$100 welcome credit — applied at checkout. No code needed" is advertised.
- Medication fee
- SynergyRX publishes prices for its longevity line only — NAD+, sermorelin, glutathione and PT-141 at $275 each and B12 methylcobalamin at $109 — and no price for any GLP-1. Third-party reviewers report compounded semaglutide at $199/month injectable or $299/month as an oral dissolving tablet, rising to $249–$299 at maintenance doses; compounded tirzepatide at $349/month injectable or $399/month oral, running $349–$449 dose-dependent; and brand-name Ozempic at $499/month with Wegovy and Mounjaro at $947/month each.
- Cancellation policy
- Not published as a clear policy. The terms address payment and refunds rather than setting out how to stop an ongoing plan.
- Refund policy
- Effectively none. The terms state that "medical consult fees are not subject to or eligible for a refund", that prescription products cannot be returned for reuse or resale, and that "all sales are final". Disputes go to mandatory arbitration under a clause that includes a class action, class arbitration and jury trial waiver.
- Insurance
- Not addressed. This is a cash-pay service, and compounded medication is not covered by insurance in any case.
- HSA / FSA
- The site advertises that treatment is "FSA eligible or HSA eligible". Eligibility is set by IRS rules and your plan administrator rather than by a seller, and compounded medication reimbursement is not guaranteed — confirm before relying on it.
Pricing details worth knowing
- We could not find a published GLP-1 price anywhere on SynergyRX's site. Everything above is third-party reported. Get your figure at checkout.
- The reported pricing scales with dose, so the entry price is not the maintenance price. Ask what you will pay at your target dose.
- Brand-name pricing reported at $947/month for Wegovy is far above Novo Nordisk's own NovoCare Pharmacy, which sells Wegovy direct at $149–$199/month.
- The $100 welcome credit is a first-order discount, not an ongoing rate.
- Consultation fees are explicitly non-refundable under the terms, and all sales are stated to be final.
Prices change. Every figure above was taken from SynergyRX's published pages or the named sources at the bottom of this review, as of August 7, 2026. Telehealth pricing in this market changes frequently, and promotional rates expire. Confirm your actual cost at checkout before enrolling.
Pros and Cons
Pros
- Names its prescribers with NPI numbers you can verify in the national registry — almost unheard of here
- Names four partner pharmacies with phone numbers and websites
- States eligibility as BMI 30+, or 27+ with a weight-related condition, matching the approved indications
- Its FAQ describes expected results accurately, as 10–20% over 6–12 months from clinical studies
- States plainly that it does not manufacture, dispense or control the formulation of medications
- Offers both compounded and brand-name pathways, and oral as well as injectable formats
- Free, discreet shipping and monthly check-ins included
Cons
- Publishes no GLP-1 price at all — only its longevity line is priced on the site
- Advertises unsourced programme outcomes: "15-20% of their body weight", "85% of patients lose 10%", "50% of patients lose 20%"
- The hero claim, "The Proven Way to lose 15% of your body weight fast!", contradicts its own more careful FAQ
- "All sales are final" and consultation fees are explicitly non-refundable
- Mandatory arbitration with a class action and jury trial waiver
- Terms of service are dated 1 January 2024 for a service launched in December 2025, and are written for a platform called CareGLP
- Registered at a Casper, Wyoming address of the kind used by registered-agent services
- Reported brand-name pricing is several times the manufacturers' own direct prices
Who SynergyRX May Be Best For
People who care most about knowing which pharmacy compounds their medication and who is prescribing it — on that dimension nobody here does better
Anyone who wants both compounded and brand-name options assessed by a named medical group
Patients who will call the pharmacies and ask before committing
Limitations
Use the disclosure. SynergyRX has given you four pharmacy phone numbers and two NPI numbers — that is an invitation to verify, and it is worth ten minutes. Ask which pharmacy will fill your prescription and whether it is a 503A pharmacy or a 503B outsourcing facility.
Do not enrol without a price. There is no published GLP-1 price, consultation fees are non-refundable, and all sales are final. Get the figure for your maintenance dose in writing before you pay anything.
Discount the outcome statistics. The 15–20% programme average and the 85/60/50% breakdown are unsourced. Its own FAQ figure — 10–20% over 6–12 months from clinical studies — is the honest one.
If you want brand-name medication, buy it from the manufacturer. Reported pricing here is $947/month for Wegovy against $149–$199/month direct from NovoCare Pharmacy.
Note that the terms you are agreeing to are dated January 2024 and written for a differently named platform.
About Compounded GLP-1s
The FDA declared the tirzepatide shortage resolved in December 2024 and the semaglutide shortage resolved in February 2025, which ended the window for compounding pharmacies to make large volumes of copies of those drugs (503A pharmacies had until April 22, 2025; 503B outsourcing facilities until May 22, 2025). Many telehealth companies continue to offer compounded GLP-1s prescribed for an individual patient — often as a personalized dose, a microdose, or a formulation combined with a vitamin such as B12 or B6. That practice sits in a contested legal area, and the FDA has continued to act. In a Federal Register notice published on May 1, 2026, the FDA proposed not to include semaglutide, tirzepatide or liraglutide on the 503B bulks list, saying it had not identified sufficient evidence of a clinical need for outsourcing facilities to compound them from bulk substances; the comment period was extended to July 30, 2026. Separately, in February 2026 the FDA issued warning letters to 30 telehealth companies over false or misleading claims about compounded GLP-1s, and it has continued: a further round dated 8 June 2026 — 25 warning letters, posted publicly on 16 June 2026 — reached companies including Medica Weight Loss, FITISH and Roen Health (RoenRx), again over false or misleading claims about compounded semaglutide and tirzepatide that the FDA said made the products misbranded under sections 502(a) and 502(bb) of the FD&C Act. The claims cited included suggesting the products were FDA-approved, implying equivalence to Ozempic, Wegovy, Mounjaro or Zepbound, and asserting the "same active ingredient" or "same results" as the approved drugs. Compounded medications are not FDA-approved, which means they have not gone through the same review as the brand-name products.
None of that is specific to SynergyRX — it applies to every provider offering compounded medication. We cover the trade-offs in detail in our guide to brand-name versus compounded GLP-1s.
Alternatives to SynergyRX
NovoCare Pharmacy
Brand-name Wegovy direct from Novo Nordisk at $149–$199/mo, against a reported $947 here
Read review →Ivím Health
Published prices and far more clinical contact, though it took an FDA warning letter in February 2026
Read review →Henry Meds
Compounded oral and injectable options with published pricing and policies
Read review →vs. CoreAge RX, our top-rated platform
Across the platforms we've reviewed, CoreAge RX remains our highest-rated option for cash-pay patients, with compounded semaglutide from $99/month and tirzepatide from $149/month including free two-day shipping. Whether it beats SynergyRX for you depends on the things this review has covered — insurance, medication type, and how much support you actually want.
Frequently Asked Questions
How much does SynergyRX cost?
It does not say, which is the main problem with it. The prices on its site cover its longevity line only — NAD+, sermorelin, glutathione and PT-141 at $275 each, B12 at $109 — and no GLP-1 price appears anywhere we could find. Third-party reviewers report compounded semaglutide from $199/month injectable or $299 as an oral tablet, compounded tirzepatide from $349/month injectable or $399 oral, both scaling with dose, and brand-name Ozempic at $499/month with Wegovy and Mounjaro at $947/month. We could not verify any of those from SynergyRX. Given that consultation fees are non-refundable and all sales are final, get your price in writing before paying anything.
Does SynergyRX say which pharmacy makes its medication?
Yes, and this is the best thing about it. It names four partner pharmacies with phone numbers and websites — Belmar Pharmacy, Strive Pharmacy, Epiq Scripts and Casa Pharma Rx. It also names the prescribing medical group, Lion MD, and two physicians with their NPI numbers, which you can look up in the national provider registry. Almost no telehealth company in this market names a single pharmacy. What SynergyRX does not say is which of the four will fill your particular prescription, or whether each is a 503A pharmacy or a 503B outsourcing facility — but it has given you the phone numbers to ask.
Are SynergyRX's weight loss claims accurate?
Its FAQ is; its marketing is not. The FAQ says clinical studies have shown average weight loss of 10–20% of body weight over 6–12 months, which is a fair description of the drug class. The homepage separately claims that patients in the SynergyRX programme lose 15–20% on average, that 85% lose 10% of body weight, 60% lose 15% and 50% lose 20%, and leads with "The Proven Way to lose 15% of your body weight fast!". Those programme figures are not sourced, and for a company launched in December 2025 they would be based on a very short history. Treat the FAQ number as the real one.
Can I get a refund from SynergyRX?
Assume not. Its terms state that medical consult fees are "not subject to or eligible for a refund", that prescription products cannot be returned for reuse or resale, and that "all sales are final". Disputes are subject to mandatory arbitration under a clause that also waives class actions, class arbitration and jury trial. That is a strict combination, and it is the reason to settle the price question before you engage rather than after.
Is SynergyRX legitimate?
The clinical side checks out better than most. It names a medical group and two physicians with NPI numbers you can verify independently, names four established compounding pharmacies, states eligibility criteria that match the FDA-approved indications, and correctly disclaims controlling the practice of medicine or the formulation of medicines. The commercial side is weaker: no published GLP-1 pricing, unsourced outcome statistics, all sales final, mandatory arbitration, a Casper, Wyoming address of the kind used by registered-agent services, and terms dated January 2024 written for a platform called CareGLP despite the service launching in December 2025.
Who should not use SynergyRX?
Anyone who needs to know what they will pay before they commit, given that consult fees are non-refundable and all sales are final. Anyone who wants brand-name medication, which is reported here at several times the manufacturers' own direct prices. Anyone uncomfortable with mandatory arbitration and a class action waiver. Separately, GLP-1 medications are not appropriate if you have a personal or family history of medullary thyroid carcinoma or MEN 2, if you are pregnant or trying to conceive, or if you have had pancreatitis.
The Verdict
SynergyRX has the most complete supply-chain disclosure we have found in this market: two named physicians with verifiable NPI numbers and four named partner pharmacies with contact details. Its eligibility criteria match the FDA-approved indications. Against that, its homepage advertises program outcomes it does not source, its GLP-1 prices are not published, and its terms state that all sales are final.
Opens SynergyRX's official site · Verify current pricing there
Compare Every Provider Side by Side
See how SynergyRX stacks up against every platform we've reviewed on price, medication type, and what's actually included.
How We Researched This Review
We compiled this review on August 7, 2026 from SynergyRX's own published pages plus independent reporting. We have not signed up for this service ourselves, and we say so rather than implying firsthand testing. Where SynergyRX does not publish a detail — refund terms, lab requirements, pharmacy partners — we've said that plainly instead of guessing.
Sources
- synergyrx.co — "The Proven Way to lose 15% of your body weight fast!"; "On average, patients in the SynergyRx program lose 15-20% of their body weight"; "85% of patients lose 10% body weight", "60% of patients lose 15% body weight", "50% of patients lose 20% body weight"; "40M+ Americans have used GLP-1"; "Join 50,000+ SynergyRx patients"; "$100 welcome credit — applied at checkout"; "FSA eligible or HSA eligible"; pricing tiles for NAD+, sermorelin, glutathione and PT-141 at $275 and B12 methylcobalamin at $109, with no GLP-1 price shown (checked August 7, 2026)
- synergyrx.co FAQ — medical team named as "Lion MD: A trusted team of nationwide medical professionals led by Dr. Ana Lisa Carr MD (NPI: 1689841744) and Dr. Kelly Tenbrink MD (NPI: 1346482684)"; pharmacy partners named as Belmar Pharmacy, Strive Pharmacy, Epiq Scripts and Casa Pharma Rx with phone numbers; eligibility stated as "A BMI of 30 or higher, or a BMI of 27+ with at least one weight-related condition"; expected results stated as "clinical studies have shown average weight loss of 10–20% of body weight over 6–12 months"
- synergyrx.co/terms — last updated 1 January 2024, written for the CareGLP platform owned by SynergyRx, "a Delaware corporation located at 5830 E 2nd St, Ste 7000 #2603, Casper, WY 82609"; "medical consult fees are not subject to or eligible for a refund"; "We cannot accept returns of prescription products for reuse or resale, and all sales are final"; mandatory arbitration provision including class action, class arbitration and jury trial waiver; "SynergyRx does not manufacture, dispense, or control the formulation of any medications prescribed"
- Third-party reviewers reporting SynergyRX GLP-1 pricing — compounded semaglutide $199/mo injectable and $299/mo oral dissolving tablet, $249–$299 at maintenance; compounded tirzepatide $349/mo injectable and $399/mo oral, $349–$449 dose-dependent; brand-name Ozempic $499/mo, Wegovy and Mounjaro $947/mo (not verified against SynergyRX's own pages)
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