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AgelessRx at a Glance
- What it is
- The only provider here that ran a placebo-controlled trial of its own therapy — and published it when the primary endpoint failed
- Medication type
- Brand-name and compounded
- Medications offered
- Microdosed compounded tirzepatide
- Compounded semaglutide, tirzepatide and liraglutide
- Brand-name Wegovy, routed through NovoCare
- Longevity therapies including low-dose naltrexone, rapamycin, metformin, NAD+ and sermorelin
- Pricing
- Microdosed tirzepatide from $159/mo on a four-month plan; no membership fee
- Insurance
- Not accepted for compounded medication, as everywhere. Brand-name Wegovy routed through NovoCare follows Novo's own self-pay pricing rather than an insurance benefit.
- Date reviewed
- August 7, 2026
How we scored it
Scores follow the published rubric in our provider comparison methodology.
Medical Disclaimer
We're not doctors, and this review is not medical advice. GLP-1 medications are prescription-only and require evaluation by a licensed healthcare provider. What works for one person may not work for another, and only a clinician who knows your history can determine whether a medication is appropriate for you. See our full medical disclaimer.
What Is AgelessRx?
AgelessRx is a longevity clinic first and a GLP-1 provider second, and that ordering explains almost everything about it. Its catalogue runs to more than thirty treatments and diagnostics — low-dose naltrexone, rapamycin, metformin, NAD+ injections, sermorelin, biological age testing — with weight-loss medication as one arm rather than the whole business.
It is also the only company across the eighty-odd providers we have reviewed that has run a randomised, double-blinded, placebo-controlled clinical trial of one of its own therapies and published the result in a peer-reviewed journal. The PEARL trial — Participatory Evaluation of Aging with Rapamycin for Longevity — randomised 114 completers aged 50 to 85 to placebo, 5mg or 10mg of weekly compounded rapamycin for 48 weeks, and was published in Aging in 2025.
What makes it worth taking seriously is that the trial did not work. Its primary outcome was visceral adiposity measured by DXA, and it did not change significantly (p = 0.942). A secondary finding — improved lean tissue mass in women taking 10mg, at both 24 and 48 weeks — was statistically significant but is a subgroup result in a small trial, and the authors listed real limitations including self-reported adherence, relatively few women, and a predominantly health-conscious sample. Adverse events were similar across groups, with more gastrointestinal symptoms on rapamycin. A company that publishes a failed primary endpoint is behaving differently from one that publishes a customer survey.
That posture carries into the weight-loss side. Its microdosing tirzepatide page states that the expected average weight loss by six months is "around 10 lbs", and that compounded products are "compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality." After reading a lot of these pages, a provider telling you to expect ten pounds is a striking thing to find.
How the Program Works
- Consultation process
- An online health-history questionnaire reviewed by a US-licensed medical provider, with no separate consultation fee published and no membership fee. Unlimited protocol adjustments and messaging are included with the GLP-1 plans, along with ongoing check-ins.
- Eligibility
- Assessed by the reviewing clinician from your health history. AgelessRx does not publish BMI thresholds, which is consistent with a longevity practice where several therapies are not weight-indicated at all.
- Provider involvement
- US-licensed medical providers prescribe; AgelessRx describes an in-house research team led by a Stanford PhD, and the PEARL trial gives that claim something to stand on. Unlimited messaging and protocol adjustment are included rather than upsold.
- Lab requirements
- Not published as a requirement. AgelessRx sells diagnostics including biological age testing as separate products, so testing is available, but nothing states whether bloodwork is expected before a GLP-1 prescription or what it costs.
- Pharmacy fulfillment
- Compounded medication is dispensed by what AgelessRx describes as a US-licensed compounding pharmacy, which it does not name. Brand-name Wegovy is routed through Novo Nordisk's own NovoCare pharmacy rather than dispensed by AgelessRx.
- Shipping frequency
- Free shipping is advertised. Plans run monthly, two-month or four-month, with the longer plans billed in full up front.
- Support services
- Unlimited messaging and protocol adjustments, ongoing check-ins, more than thirty other treatments and diagnostics on the same account, and a published research programme.
AgelessRx Pricing
- Membership fee
- None published.
- Medication fee
- Microdosing tirzepatide is published at "$159 / mo", which applies to four-month plans billed in full; monthly and two-month plans are also offered at higher effective rates. Independent reviewers report compounded semaglutide from $139/month, compounded tirzepatide from $249/month, compounded liraglutide from $149/month, microdosing GLP-1 from $99/month, low-dose naltrexone at $25 and NAD+ injections at $235. Brand-name Wegovy is routed through NovoCare at Novo's own pricing.
- Cancellation policy
- "Pause or cancel anytime" is stated on the product pages. Because longer plans are billed in full at the start, cancelling mid-plan means you have already paid for the remainder — ask what happens to the balance before choosing a four-month term.
- Refund policy
- Not published in a form we could reach. Given that four-month plans are prepaid, get the refund position in writing before committing to one.
- Insurance
- Not accepted for compounded medication, as everywhere. Brand-name Wegovy routed through NovoCare follows Novo's own self-pay pricing rather than an insurance benefit.
- HSA / FSA
- Not addressed. Prescription costs are commonly HSA/FSA-eligible; confirm with your administrator, and note compounded medication reimbursement is not guaranteed.
Pricing details worth knowing
- The advertised $159 is the four-month rate billed in full — roughly $636 up front. Monthly billing costs more per month.
- There is no membership fee, so the medication price is the whole price.
- We could not verify every figure above from AgelessRx's own pages; only the microdosing tirzepatide price is quoted directly from its product page. Confirm yours at checkout.
- AgelessRx does not publish a single consolidated price list — each treatment has its own page, which makes comparison shopping across its own catalogue harder than it should be.
- Routing brand-name Wegovy through NovoCare rather than marking it up is the right thing to do, and the opposite of what several providers in this comparison do.
Prices change. Every figure above was taken from AgelessRx's published pages or the named sources at the bottom of this review, as of August 7, 2026. Telehealth pricing in this market changes frequently, and promotional rates expire. Confirm your actual cost at checkout before enrolling.
Pros and Cons
Pros
- Ran a randomised, double-blinded, placebo-controlled trial of its own therapy and published it in a peer-reviewed journal — unique in this comparison
- Published that trial's primary endpoint as not met, rather than leading with the favourable subgroup
- States an expected average weight loss of around 10 lb at six months on microdosing — the most restrained efficacy messaging we have seen in this market
- Explicitly states that the FDA has not reviewed or approved compounded products for safety, efficacy or quality
- No membership fee, so there is only one number to compare
- Routes brand-name Wegovy through NovoCare instead of marking it up
- Unlimited messaging and protocol adjustments included
- A microdosing option from around $99–$159/mo for people who want the lowest effective dose
Cons
- No consolidated price list — each treatment sits on its own page
- The headline $159 is a four-month rate billed in full, roughly $636 up front
- No published refund policy we could reach
- Does not name its compounding pharmacy or publish lab requirements or states served
- The "80% of users noticed moderate weight loss" figure is a company claim, not a trial result
- The PEARL trial used compounded rapamycin, which carries its own regulatory questions
- The longevity catalogue includes peptides whose compounding status the FDA has not settled
Who AgelessRx May Be Best For
People who want a longevity practice rather than a single-purpose weight service, with GLP-1s as one option among many
Anyone drawn to microdosing who wants realistic expectations set in advance
Readers who weight a company's willingness to publish a failed trial above its marketing
Limitations
Do not read the PEARL trial as evidence that rapamycin extends healthspan. Its primary endpoint was not met. What it supports is a safety and tolerability signal at low weekly doses over 48 weeks in 114 people, plus a subgroup finding on lean mass in women at 10mg that needs replication.
Microdosing is not a cheaper route to the same result. AgelessRx says so itself — around 10 lb at six months is roughly a tenth of what full-dose tirzepatide produced in SURMOUNT-1. If substantial weight loss is your goal, price the standard dose.
Ask what happens to a four-month prepaid plan if you stop. That is the single most important unanswered question here.
Ask which pharmacy compounds your medication and whether it is 503A or 503B.
If you want brand-name medication, note that AgelessRx routing you to NovoCare means you could also go to NovoCare directly.
About Compounded GLP-1s
The FDA declared the tirzepatide shortage resolved in December 2024 and the semaglutide shortage resolved in February 2025, which ended the window for compounding pharmacies to make large volumes of copies of those drugs (503A pharmacies had until April 22, 2025; 503B outsourcing facilities until May 22, 2025). Many telehealth companies continue to offer compounded GLP-1s prescribed for an individual patient — often as a personalized dose, a microdose, or a formulation combined with a vitamin such as B12 or B6. That practice sits in a contested legal area, and the FDA has continued to act. In a Federal Register notice published on May 1, 2026, the FDA proposed not to include semaglutide, tirzepatide or liraglutide on the 503B bulks list, saying it had not identified sufficient evidence of a clinical need for outsourcing facilities to compound them from bulk substances; the comment period was extended to July 30, 2026. Separately, in February 2026 the FDA issued warning letters to 30 telehealth companies over false or misleading claims about compounded GLP-1s, and it has continued: a further round dated 8 June 2026 — 25 warning letters, posted publicly on 16 June 2026 — reached companies including Medica Weight Loss, FITISH and Roen Health (RoenRx), again over false or misleading claims about compounded semaglutide and tirzepatide that the FDA said made the products misbranded under sections 502(a) and 502(bb) of the FD&C Act. The claims cited included suggesting the products were FDA-approved, implying equivalence to Ozempic, Wegovy, Mounjaro or Zepbound, and asserting the "same active ingredient" or "same results" as the approved drugs. Compounded medications are not FDA-approved, which means they have not gone through the same review as the brand-name products.
None of that is specific to AgelessRx — it applies to every provider offering compounded medication. We cover the trade-offs in detail in our guide to brand-name versus compounded GLP-1s.
Alternatives to AgelessRx
NovoCare Pharmacy
Where AgelessRx routes brand-name Wegovy anyway — $149–$199/mo direct, with no intermediary
Read review →Maximus
Another longevity-first service with a broad hormone and metabolic catalogue
Read review →Henry Meds
If you want compounded GLP-1s specifically, with clearer published policies
Read review →vs. CoreAge RX, our top-rated platform
Across the platforms we've reviewed, CoreAge RX remains our highest-rated option for cash-pay patients, with compounded semaglutide from $99/month and tirzepatide from $149/month including free two-day shipping. Whether it beats AgelessRx for you depends on the things this review has covered — insurance, medication type, and how much support you actually want.
Frequently Asked Questions
What is the PEARL trial and does it prove anything?
PEARL — Participatory Evaluation of Aging with Rapamycin for Longevity — is a 48-week decentralised, double-blinded, randomised, placebo-controlled trial run by AgelessRx and published in Aging in 2025. It randomised 114 completers aged 50 to 85 to placebo, 5mg or 10mg of weekly compounded rapamycin. Its primary outcome, visceral adiposity measured by DXA, did not change significantly (p = 0.942). Lean tissue mass improved significantly in women taking 10mg at 24 and 48 weeks. Adverse events were similar across groups, with more gastrointestinal symptoms on rapamycin. So it does not prove rapamycin works for healthy ageing. It provides a safety and tolerability signal and one subgroup finding worth following up — and the fact that a commercial provider published a null primary result at all is the most useful thing about it.
How much does AgelessRx cost?
There is no membership fee, so you pay for treatment only. Microdosing tirzepatide is published at $159/month, which is the rate on a four-month plan billed in full — around $636 up front — with monthly and two-month plans costing more per month. Independent reviewers report compounded semaglutide from $139/month, compounded tirzepatide from $249, compounded liraglutide from $149, microdosing GLP-1 from $99, low-dose naltrexone at $25 and NAD+ injections at $235. AgelessRx does not publish a single consolidated price list, so confirm your figure at checkout.
Is microdosing a GLP-1 worth it?
It depends entirely on what you want, and AgelessRx is unusually straight about the trade. Its own page says the expected average weight loss by six months is around 10 lb. For comparison, the highest tirzepatide dose produced about 21% of body weight over 72 weeks in SURMOUNT-1. So microdosing is a plausible option if your goal is modest change with fewer side effects at a lower price — and it is not the route to substantial weight loss. Being told that before you buy is worth something.
Does AgelessRx sell brand-name GLP-1s?
It facilitates brand-name Wegovy through Novo Nordisk's own NovoCare pharmacy rather than dispensing and marking it up. That is a genuinely consumer-friendly choice — several providers in this comparison resell brand-name medication at four to seven times what the manufacturer charges. It also means that if brand-name is all you want, you can go to NovoCare directly and skip the intermediary.
Is compounded medication from AgelessRx FDA-approved?
No, and AgelessRx says so in plain terms on its own product pages: compounded products are "compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality." That is the correct statement and a surprising number of its competitors do not make it.
Who should not use AgelessRx?
Anyone who wants substantial weight loss quickly and would be better served pricing a standard dose. Anyone who needs to know their refund rights before prepaying, since four-month plans are billed in full and no refund policy is published. Anyone who wants brand-name medication, who can go to NovoCare directly. Separately, GLP-1 medications are not appropriate if you have a personal or family history of medullary thyroid carcinoma or MEN 2, if you are pregnant or trying to conceive, or if you have had pancreatitis.
The Verdict
AgelessRx is a longevity telehealth service with a GLP-1 arm, offering microdosed tirzepatide from $159/month and compounded semaglutide reported from $139, with no membership fee. It is the only company in this comparison to have run and published a randomised placebo-controlled trial of one of its own treatments, and the only one whose weight-loss expectations are stated conservatively enough to be believable.
Opens AgelessRx's official site · Verify current pricing there
Compare Every Provider Side by Side
See how AgelessRx stacks up against every platform we've reviewed on price, medication type, and what's actually included.
How We Researched This Review
We compiled this review on August 7, 2026 from AgelessRx's own published pages plus independent reporting. We have not signed up for this service ourselves, and we say so rather than implying firsthand testing. Where AgelessRx does not publish a detail — refund terms, lab requirements, pharmacy partners — we've said that plainly instead of guessing.
Sources
- agelessrx.com — "Lowest price ever on Microdosing Tirzepatide | $159/month"; "Answer a few questions about your health history to be reviewed by a US-licensed medical provider"; "Fast, free shipping"; "5,200+ participants completed clinical studies on efficacy of AgelessRx therapies"; 30+ treatments and diagnostics (checked August 7, 2026)
- agelessrx.com microdosing tirzepatide page — "$159 / mo" applying to four-month plans billed in full, with monthly and two-month plans also offered; "Pause or cancel anytime"; unlimited protocol adjustments and messaging; expected average weight loss by six months "around 10 lbs"; "80% of users noticed moderate weight loss"; "compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality" (checked August 7, 2026)
- Aging (Albany NY), 2025 — PEARL trial: 48-week decentralised, double-blinded, randomised, placebo-controlled trial of weekly 5mg or 10mg compounded rapamycin vs placebo in 114 completers aged 50–85. Primary outcome visceral adiposity by DXA not met (p = 0.942); lean tissue mass improved significantly for women on 10mg at 24 and 48 weeks; adverse and serious adverse events similar across groups; stated limitations included self-reported adherence, relatively few women and a predominantly health-conscious sample
- Third-party reviewers reporting AgelessRx pricing — compounded semaglutide from $139/mo, compounded tirzepatide from $249/mo, compounded liraglutide from $149/mo, microdosing GLP-1 from $99/mo, low-dose naltrexone $25, NAD+ injections $235, no membership fee, and brand-name Wegovy routed through NovoCare (not verified against AgelessRx's own pages)
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